Description

1-Cyclopropoxy-4-Iodo-Benzene is a high-purity aromatic ether building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of a cyclopropoxy ether group and an iodine atom, which serves as a versatile handle for further functionalization via cross-coupling reactions. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to construct complex molecular architectures for new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-infective agents.
• Agrochemical Research: Used to develop new herbicides, fungicides, and insecticides by incorporating the cyclopropoxy-phenyl moiety into lead structures.
• Ligand & Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis.
• Material Science: Employed in the creation of organic electronic materials and liquid crystals due to its rigid, substituted benzene core.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for Suzuki, Stille, and Sonogashira couplings to form biaryl and extended π-conjugated systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	1-Cyclopropoxy-4-Iodo-Benzene
CAS No.	1243459-31-5
Molecular Formula	C9H9IO
Molecular Weight	260.07 g/mol
Synonyms	4-Iodophenyl cyclopropyl ether; Cyclopropyl 4-iodophenyl ether; p-Iodophenyl cyclopropyl ether; 1-Iodo-4-(cyclopropyloxy)benzene; Benzene, 1-cyclopropoxy-4-iodo-; 4-(Cyclopropoxy)iodobenzene; (4-Iodophenoxy)cyclopropane
EINECS	Contact for details

Quality Control

Every batch of 1-Cyclopropoxy-4-Iodo-Benzene is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure product integrity and traceability. Our standard quality commitment includes rigorous purity verification by HPLC/GC, identity confirmation via spectroscopic methods (NMR, IR), and control of key impurities. Certificates of Analysis (COA) detailing all test results are available for each lot and provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.