Description

(R)-3-Methyl-1-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Butan-1-Amine Hydrochloride is a high-purity chiral amine boronic ester derivative, a critical building block in modern pharmaceutical and agrochemical synthesis. Its value lies in its role as a versatile intermediate for the construction of complex molecules via cross-coupling reactions, enabling the development of novel active ingredients. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality chiral synthons for their development pipelines.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a protected boronic acid equivalent for the formation of carbon-carbon bonds, a fundamental transformation in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring chiral specificity.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: A precursor for functionalized polymers and advanced organic materials with specific stereochemical properties.
• Process Chemistry & Scale-Up: Supports route scouting and optimization from laboratory to pilot plant and commercial manufacturing scales.

Basic Information

Product Name	(R)-3-Methyl-1-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Butan-1-Amine Hydrochloride
CAS No.	1243174-57-3
Molecular Formula	C11H25BClNO2
Molecular Weight	249.59 g/mol
Synonyms	(R)-1-Amino-3-methylbutylboronic acid pinacol ester hydrochloride; (R)-3-Methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butylamine hydrochloride; (R)-Valinol-derived MIDA boronate hydrochloride (analogous class); (R)-1-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylbutan-1-amine HCl; Chiral amine pinacol boronate hydrochloride; (R)-3-Methyl-1-(pinacolatoboryl)butan-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-Methyl-1-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Butan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.