Description

2-(4-Ethoxy-3-(Trifluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in its role as a versatile and stable intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality precursors for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing the 4-ethoxy-3-(trifluoromethyl)phenyl moiety.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that benefit from the chemical properties of the trifluoromethyl group.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl bonds, a cornerstone of modern organic synthesis.
• Chemical Library Development: Utilized in medicinal chemistry for the parallel synthesis of diverse compound libraries to screen for new biological activity.
• Ligand and Catalyst Preparation: Acts as a starting material for synthesizing specialized ligands and organometallic catalysts.

Basic Information

Product Name	2-(4-Ethoxy-3-(Trifluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1243143-46-5
Molecular Formula	C₁₅H₂₀BF₃O₃
Molecular Weight	316.13 g/mol
Synonyms	4-Ethoxy-3-(trifluoromethyl)phenylboronic acid pinacol ester; (4-Ethoxy-3-(trifluoromethyl)phenyl)boronic acid pinacol ester; 2-[4-Ethoxy-3-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Trifluoromethyl-4-ethoxyphenylboronic acid pinacol ester; Pinacol [4-ethoxy-3-(trifluoromethyl)phenyl]boronate; B-[4-Ethoxy-3-(trifluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(4-Ethoxy-3-(Trifluoromethyl)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B, ¹⁹F), and GC/MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance in GMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) and handle it in a dry environment to prevent hydrolysis and maintain stability. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.