Description

4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide is a high-purity, synthetically valuable boronic ester derivative, serving as a critical building block in modern organic synthesis. Its core value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries, where it is used to develop new active ingredients and functional molecules. The CAS number for this product is 1242422-55-4.

Application

This versatile boronic ester is primarily employed as a key synthetic intermediate. Its applications include:

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides by facilitating the introduction of the benzamide moiety.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Acts as a handle for bioconjugation and the development of activity-based probes and inhibitors.
• Academic & R&D Laboratories: A standard reagent for methodological development in palladium-catalyzed coupling reactions and boronic acid chemistry.

Basic Information

Product Name	4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide
CAS No.	1242422-55-4
Molecular Formula	C13H17BClNO3
Molecular Weight	281.54 g/mol
Synonyms	4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 3-Aminoformyl-4-chlorophenylboronic acid pinacol ester; 4-Chloro-3-(pinacolatoboryl)benzamide; Benzamide, 4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1242422-55-4; 4-Chloro-3-borono-benzamide pinacol ester
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Standard quality checks include HPLC for assay and purity, NMR for structural confirmation, and Karl Fischer titration for water content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.