Description

1-Bromo-2-(Difluoromethoxy)-4,5-Difluoro-Benzene is a high-value, multi-fluorinated aromatic building block. This compound is critical for introducing the difluoromethoxy and halogenated aryl motifs into advanced molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, where its unique fluorine substitution pattern can modulate lipophilicity, metabolic stability, and biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances compound efficacy and environmental profile.
• Liquid Crystal Materials (LCs): Serves as a fluorinated core component in the synthesis of high-performance liquid crystals for display technologies.
• Organic Electronics: Employed as a building block for electron-transport materials, semiconductors, and other functional materials in OLEDs and OFETs.
• Fluorinated Polymer Chemistry: Acts as a monomer or modifier to introduce fluorine atoms into polymer chains, improving chemical resistance and lowering surface energy.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.

Basic Information

Product Name	1-Bromo-2-(Difluoromethoxy)-4,5-Difluoro-Benzene
CAS No.	1242258-46-3
Molecular Formula	C7H3BrF4O
Molecular Weight	258.99 g/mol
Synonyms	2-Bromo-1-(difluoromethoxy)-4,5-difluorobenzene; 4,5-Difluoro-2-bromo-1-(difluoromethoxy)benzene; 1-Bromo-2-(difluoromethoxy)-4,5-difluorobenzene; Benzene, 1-bromo-2-(difluoromethoxy)-4,5-difluoro-; 4,5-Difluoro-2-(difluoromethoxy)bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(Difluoromethoxy)-4,5-Difluoro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed in a dry environment to prevent moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.