Description

4-(Difluoromethoxy)-2-Fluorobromobenzene is a high-purity fluorinated aromatic bromide building block, essential for advanced organic synthesis. Its value lies in its unique difluoromethoxy and halogen substituents, which enable precise molecular modifications to enhance the biological activity and metabolic stability of target compounds. This intermediate is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the difluoromethoxy group can improve lipophilicity and environmental stability.
• Liquid Crystal Material Precursor: Serves as a building block for fluorinated liquid crystals used in advanced display technologies.
• Functional Material Development: Employed in the synthesis of organic semiconductors, OLED materials, and other specialty polymers requiring specific electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Medicinal Chemistry Research: Facilitates structure-activity relationship (SAR) studies by allowing the introduction of fluorinated motifs into lead compounds.

Basic Information

Product Name	4-(Difluoromethoxy)-2-Fluorobromobenzene
CAS No.	1242258-38-3
Molecular Formula	C7H4BrF3O
Molecular Weight	241.01 g/mol
Synonyms	2-Fluoro-4-(difluoromethoxy)bromobenzene; 1-Bromo-2-fluoro-4-(difluoromethoxy)benzene; Benzene, 1-bromo-2-fluoro-4-(difluoromethoxy)-; 4-Bromo-3-fluoroanisole, difluoro; 2-Fluoro-4-difluoromethoxybromobenzene; 4-(Difluoromethoxy)-2-fluorophenyl bromide
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)-2-Fluorobromobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and GC-MS, 1H/19F NMR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with complete chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The compound is light-sensitive and should be stored away from light. Handle and store under an inert atmosphere if prolonged storage is required.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.