Description

5-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine is a high-value, multi-functional organic building block that serves as a critical intermediate in modern synthetic chemistry. Its core value lies in the strategic combination of a protected pyrrolopyridine core, a boronic ester pinacol group, and a triisopropylsilyl (TIPS) protecting group, enabling precise and complex molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients through cross-coupling reactions and targeted functionalization.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, especially in oncology and antiviral research, via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its fluorine and heterocyclic structure for bioactivity.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorescent tags or molecular probes for studying biological systems.
• Process Chemistry & Scale-up: An important intermediate for the kilogram-scale production of target molecules under GMP or non-GMP conditions.
• Academic & R&D Laboratories: A versatile reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	5-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.	1241950-72-0
Molecular Formula	C22H36BFNO2Si
Molecular Weight	403.43 g/mol
Synonyms	1-(Triisopropylsilyl)-5-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-1-(triisopropylsilyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 4-Boronic acid, 5-fluoro-1H-pyrrolo[2,3-b]pyridine-4-, 1-(1,1-dimethylethyl) 1,1-dimethylethyl ester, 1-(triisopropylsilyl)-; TIPS-5-Fluoro-4-BPin-pyrrolopyridine; 5-Fluoro-4-(pinacolboron)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring consistency and reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.