Description

Methyl 4-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Cyclopropyl)Benzoate is a high-value, advanced pharmaceutical intermediate featuring a cyclopropyl ring and a protected boronic ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry and drug discovery. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring cyclopropyl and aryl-boronate motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial coupling partner for the formation of carbon-carbon bonds between aromatic rings, a cornerstone of modern organic synthesis.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Agrochemical Synthesis: Employed in the research and development of advanced crop protection agents and pesticides.
• Material Science Precursor: Potential use in the development of organic electronic materials and functional polymers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and scale-up services for the life sciences industry.

Basic Information

Product Name	Methyl 4-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Cyclopropyl)Benzoate
CAS No.	1240492-31-2
Molecular Formula	C₁₇H₂₃BO₄
Molecular Weight	302.18 g/mol
Synonyms	4-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropyl)benzoic acid methyl ester; Methyl 4-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropyl]benzoate; Benzoic acid, 4-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropyl]-, methyl ester; 1240492-31-2; Cyclopropylboronic acid pinacol ester benzoate derivative
EINECS	Contact for details

Quality Control

Our Methyl 4-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Cyclopropyl)Benzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.