Description

3'-Fluoro-5'-(Pentafluorosulfur)Acetophenone is a high-value fluorinated aromatic ketone building block, distinguished by its unique combination of fluorine and pentafluorosulfur substituents. This structure is critical for modulating the electronic properties, lipophilicity, and metabolic stability of advanced molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-targeted therapeutic programs.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and pesticides with enhanced efficacy and environmental profile.
• Material Science: Serves as a precursor for specialty polymers and liquid crystals where fluorine content imparts desirable thermal and chemical resistance.
• Chemical Synthesis: A versatile reagent for introducing the pentafluorosulfanyl (SF5) group, a "super-trifluoromethyl" bioisostere, into complex organic frameworks.
• R&D and Process Chemistry: Essential for route scouting, lead optimization, and scale-up studies in fine chemical and contract manufacturing organizations (CMOs).

Basic Information

Product Name	3'-Fluoro-5'-(Pentafluorosulfur)Acetophenone
CAS No.	1240257-57-1
Molecular Formula	C8H4F6OS
Molecular Weight	262.17 g/mol
Synonyms	1-[3-Fluoro-5-(pentafluoro-λ6-sulfanyl)phenyl]ethan-1-one; 3-Fluoro-5-(pentafluorosulfanyl)acetophenone; 3-Fluoro-5-SF5-acetophenone; 3'-Fluoro-5'-SF5-acetophenone; 1-(3-Fluoro-5-(pentafluorosulfanyl)phenyl)ethanone; Acetophenone, 3'-fluoro-5'-(pentafluorosulfur)-; 1240257-57-1
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-5'-(Pentafluorosulfur)Acetophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.