Description

3-Methyl-5-(Pentafluorosulfur)Benzylbromide is a high-value organofluorine building block, specifically a benzyl bromide derivative functionalized with a pentafluorosulfur (SF5) group. This compound is critical for introducing the unique SF5 moiety into target molecules, a modification known to dramatically enhance metabolic stability, lipophilicity, and overall bioactivity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents where the SF5 group improves pharmacokinetic properties.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the SF5 group's ability to increase compound stability and membrane permeability.
• Liquid Crystal & Advanced Material Synthesis: Serves as a precursor for creating SF5-containing aromatic cores used in liquid crystal displays (LCDs) and other high-performance electronic materials.
• Ligand & Catalyst Development: Employed in organometallic chemistry to create specialized ligands for catalysis, where the strong electron-withdrawing nature of the SF5 group can fine-tune metal center reactivity.
• Fluorine-Containing Polymer Modification: Acts as a monomer or grafting agent for incorporating the thermally and chemically stable SF5 group into polymer backbones, enhancing material properties.
• Positron Emission Tomography (PET) Tracer Precursor: Potential use in radiochemistry for synthesizing SF5-labeled tracers for medical imaging, given the fluorine content.

Basic Information

Product Name	3-Methyl-5-(Pentafluorosulfur)Benzylbromide
CAS No.	1240257-48-0
Molecular Formula	C8H6BrF5S
Molecular Weight	285.10 g/mol
Synonyms	5-(Bromomethyl)-1-methyl-3-(pentafluoro-λ6-sulfanyl)benzene; 3-Methyl-5-(SF5)benzyl bromide; 1-Methyl-3-(pentafluorosulfanyl)-5-(bromomethyl)benzene; (3-Methyl-5-(pentafluorosulfur)phenyl)methyl bromide; α-Bromo-3-methyl-5-(pentafluorosulfanyl)toluene; SF5-Benzyl Bromide Derivative; CAS 1240257-48-0
EINECS	Contact for details

Quality Control

Every batch of 3-Methyl-5-(Pentafluorosulfur)Benzylbromide is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency suitable for sensitive R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.