Description

2-[1-(2-Chlorophenyl)Ethenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a vinylboronic ester, widely used in advanced organic synthesis. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and agrochemical development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biphenyl or styrenyl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific chlorinated aromatic structures.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, such as polymers and small molecules for OLEDs and semiconductors.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to introduce the 2-chlorostyrenyl fragment into target molecules.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules and probes for studying biological pathways and target engagement.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands and organometallic catalysts.

Basic Information

Product Name	2-[1-(2-Chlorophenyl)Ethenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1239700-56-1
Molecular Formula	C14H18BClO2
Molecular Weight	264.55 g/mol
Synonyms	(2-Chlorostyryl)boronic acid pinacol ester; 2-(2-Chlorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-(2-Chlorophenyl)vinylboronic acid pinacol ester; 2-(1-(2-Chlorophenyl)vinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Chlorostyryl)BPin; 2-Chlorostyrene pinacol boronate; 2-Chlorostyryl pinacolboronate; 2-Chlorostyryl-Bpin
EINECS	Contact for details

Quality Control

Our 2-[1-(2-Chlorophenyl)Ethenyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.