Description

1-Benzyl-3,3-Difluoropiperidin-4-Ol is a high-value, fluorinated piperidine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a benzyl group and geminal difluorination, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the creation of novel pesticides and herbicides, where the fluorine atoms can enhance biological activity and environmental stability.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization to modulate the pharmacokinetic and pharmacodynamic properties of potential therapeutics.
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study enzyme function and biological pathways.
• Ligand and Catalyst Development: Utilized in the synthesis of specialized ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Building Block: Acts as a valuable source of a difluorinated piperidine moiety for introducing fluorine into complex molecular architectures.

Basic Information

Product Name	1-Benzyl-3,3-Difluoropiperidin-4-Ol
CAS No.	1239596-53-2
Molecular Formula	C12H15F2NO
Molecular Weight	227.25 g/mol
Synonyms	4-Piperidinol, 1-(phenylmethyl)-3,3-difluoro-; 3,3-Difluoro-1-benzylpiperidin-4-ol; 1-Benzyl-3,3-difluoropiperidin-4-ol; 1-Benzyl-3,3-difluoro-4-hydroxypiperidine; 3,3-Difluoro-1-(phenylmethyl)piperidin-4-ol; 4-Hydroxy-1-benzyl-3,3-difluoropiperidine
EINECS	Contact for details

Quality Control

Our 1-Benzyl-3,3-Difluoropiperidin-4-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.