Description

3-(tert-Butoxycarbonyl)-3-Azabicyclo[4.1.0]Heptane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique azabicyclo[4.1.0]heptane scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with potential biological activity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, pain management, and other therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained bicyclic structure.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for candidate drugs.
• Proteolysis Targeting Chimera (PROTAC) & Molecular Glue Development: The carboxylic acid functionality and rigid core make it a potential linker or component in the design of targeted protein degraders.
• Peptidomimetic Synthesis: Incorporated into peptide analogs to enhance metabolic stability, bioavailability, and receptor selectivity.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying enzyme function and biological pathways.

Basic Information

Product Name	3-(tert-Butoxycarbonyl)-3-Azabicyclo[4.1.0]Heptane-1-Carboxylic Acid
CAS No.	1239421-67-0
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	1-N-Boc-3-azabicyclo[4.1.0]heptane-3-carboxylic acid; 3-[(tert-Butoxy)carbonyl]-3-azabicyclo[4.1.0]heptane-1-carboxylic acid; 3-Azabicyclo[4.1.0]heptane-1-carboxylic acid, 3-[(1,1-dimethylethoxy)carbonyl]-; 3-(Boc)-3-azabicyclo[4.1.0]heptane-1-carboxylic acid; tert-Butyl 1-carboxy-3-azabicyclo[4.1.0]heptane-3-carboxylate; Bicyclo[4.1.0]heptane-1-carboxylic acid, 3-[(1,1-dimethylethoxy)carbonyl]-3-aza-; AZBC building block
EINECS	Contact for details

Quality Control

Our 3-(tert-Butoxycarbonyl)-3-Azabicyclo[4.1.0]Heptane-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.