Description

1H-Pyrazol-3-Ylboronic Acid is a versatile and high-value boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on novel active ingredients, particularly in the development of heterocyclic scaffolds. Its reliable performance makes it a sought-after intermediate for creating complex molecules in high-value applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those containing pyrazole or fused heterocyclic cores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and advanced polymers.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a pivotal boronic acid partner for coupling with various aryl/heteroaryl halides to construct biaryl structures.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and tools for studying biological systems and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and scale-up projects under cGMP or research-grade conditions.

Basic Information

Product Name	1H-Pyrazol-3-Ylboronic Acid
CAS No.	1239363-47-3
Molecular Formula	C3H5BN2O2
Molecular Weight	111.89 g/mol
Synonyms	3-Pyrazolylboronic Acid; 1H-Pyrazol-3-ylboronic Acid; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; Pyrazol-3-ylboronic Acid; 1H-Pyrazol-5-ylboronic Acid (tautomer); 3-Boronopyrazole; 5-Pyrazolylboronic Acid
EINECS	Contact for details

Quality Control

Our 1H-Pyrazol-3-Ylboronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including NMR, HPLC, and elemental analysis, to confirm identity and purity. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We support development and commercial projects with material suitable for research use and can supply grades aligned with cGMP guidelines for advanced applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.