Description

Azetidine, 3-(3,4-Difluorophenoxy)-, Hydrochloride (1:1) is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is essential for medicinal chemistry research, process development, and scale-up manufacturing within the global pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel drug candidates, especially in neurological and metabolic disease research.
• Medicinal Chemistry R&D: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry & Scale-Up: Serves as a key raw material for process development and pilot-scale to commercial-scale API manufacturing.
• Bioconjugation & Probe Development: Utilized in the development of chemical probes and targeted conjugates for biological research and diagnostic applications.
• Academic & Institutional Research: Employed in university and research institute laboratories for cutting-edge chemical and pharmacological studies.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for client-specific synthesis projects.

Basic Information

Product Name	Azetidine, 3-(3,4-Difluorophenoxy)-, Hydrochloride (1:1)
CAS No.	1236862-32-0
Molecular Formula	C9H9F2NO•HCl
Molecular Weight	221.63 g/mol (Free base: 185.17 g/mol)
Synonyms	3-(3,4-Difluorophenoxy)azetidine hydrochloride; 3-(3,4-Difluorophenoxy)azetidine HCl; Azetidine, 3-(3,4-difluorophenoxy)-, hydrochloride; 1:1 Salt of 3-(3,4-Difluorophenoxy)azetidine and HCl; 3-(3,4-DFPO)Azetidine Hydrochloride; (3,4-Difluorophenoxy)azetidinium chloride
EINECS	Contact for details

Quality Control

Our Azetidine, 3-(3,4-Difluorophenoxy)-, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and relevant industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.