Description

Methyl 5-Ethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiophene-2-Carboxylate CAS NO 1235545-46-6 is a high-purity, synthetically valuable organoboron building block, specifically a thiophene boronic ester derivative. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern organic synthesis for constructing complex molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to create novel active ingredients and advanced functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates containing thiophene heterocycles, particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the thiophene moiety can impart specific biological activity and environmental stability.
• Organic Light-Emitting Diodes (OLEDs): Serves as a precursor for synthesizing novel electron-transport or emissive layer materials in display and lighting technologies.
• Polymer and Material Science: Enables the incorporation of thiophene units into conjugated polymers for applications in organic photovoltaics (OPVs), field-effect transistors (OFETs), and conductive polymers.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D labs exploring new synthetic pathways, heterocyclic chemistry, and boron-based methodologies.
• Ligand and Catalyst Development: Can be used to create novel bidentate or polydentate ligands for transition metal catalysis.

Basic Information

Item	Details
Product Name	Methyl 5-Ethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiophene-2-Carboxylate
CAS No.	1235545-46-6
Molecular Formula	C14H21BO4S
Molecular Weight	296.19 g/mol
Synonyms	5-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylic acid methyl ester; Methyl 5-ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate; 5-Ethyl-4-(pinacolatoboryl)thiophene-2-carboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 5-ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Pinacol 5-Ethyl-4-(methoxycarbonyl)thiophen-2-ylboronate
EINECS	Contact for details

Quality Control

Our Methyl 5-Ethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiophene-2-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR (¹H and ¹³C), and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.