Description

n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Acetamide CAS NO 1235450-93-7 is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is a critical building block in modern medicinal chemistry, enabling key carbon-carbon bond-forming reactions like the Suzuki-Miyaura cross-coupling. It is primarily utilized by research institutions and pharmaceutical manufacturers for the development and scalable synthesis of novel active pharmaceutical ingredients (APIs) and other complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as an organoboron reagent for constructing biaryl and heterobiaryl structures, a cornerstone of modern drug discovery.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Material Science: Potential building block for creating organic electronic materials and advanced polymers.
• Chemical Biology & Proteomics: Can be employed as a molecular probe or linker in bioconjugation and target identification studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and process development projects.

Basic Information

Product Name	n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Acetamide
CAS No.	1235450-93-7
Molecular Formula	C15H22BNO3
Molecular Weight	275.15 g/mol
Synonyms	N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamide; 4-(Acetamidomethyl)phenylboronic acid pinacol ester; 2-[4-(Acetamidomethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Acetamide, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]-; (4-(Acetamidomethyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Acetamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We can support development projects with material produced under ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.