Description

Pyrimidine, 2-Ethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity boronic ester derivative of a substituted pyrimidine, serving as a critical advanced pharmaceutical intermediate and building block in modern synthetic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and materials science who require reliable, high-quality organoboron reagents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific pyrimidine scaffolds.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and enzyme inhibitors for target identification and validation.
• Academic & Industrial R&D: A versatile reagent for methodology development and constructing complex heterocyclic compounds in organic synthesis laboratories.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Pyrimidine, 2-Ethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1235450-87-9
Molecular Formula	C₁₄H₂₁BN₂O₂
Molecular Weight	260.14 g/mol
Synonyms	2-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-ethylpyrimidine; 2-Ethylpyrimidine-5-boronic acid pinacol ester; 2-Ethyl-5-pyrimidineboronic acid pinacol ester; (2-Ethylpyrimidin-5-yl)boronic acid pinacol ester; 5-(2-Ethylpyrimidin-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; PINACOL 2-ETHYL-5-PYRIMIDINEBORONATE
EINECS	Contact for details

Quality Control

Our Pyrimidine boronic ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.