Description

1-(Ethoxymethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a high-purity, advanced pharmaceutical intermediate and building block for organic synthesis. This compound matters because it combines a pyrazole core with a protected boronic ester functional group, enabling critical cross-coupling reactions like the Suzuki-Miyaura reaction to construct complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the efficient synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester moiety serves as a crucial coupling partner for forming carbon-carbon bonds with aryl/heteroaryl halides.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Building block for creating organic electronic materials, such as those used in OLEDs or organic semiconductors.
• Chemical Biology Probes: Useful for synthesizing labeled compounds or probes for studying biological systems and target engagement.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for drug discovery campaigns.

Basic Information

Product Name	1-(Ethoxymethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.	1235406-71-9
Molecular Formula	C12H21BN2O3
Molecular Weight	252.12 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(ethoxymethyl)-1H-pyrazole; 1H-Pyrazole, 1-(ethoxymethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-(Ethoxymethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 1-(Ethoxymethyl)pyrazole-5-boronic acid pinacol ester; 5-Borono-1-(ethoxymethyl)pyrazole pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(Ethoxymethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity during handling. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.