Description

7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,4-Tetrahydroquinoline is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters because it enables efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and advanced material research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing a tetrahydroquinoline scaffold.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring selective coupling reactions.
• Material Science Research: Serves as a building block for creating organic semiconductors, liquid crystals, and advanced polymers with tailored electronic properties.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group acts as a stable, handle for palladium-catalyzed coupling with aryl/vinyl halides or triflates.
• Chemical Biology Probes: Utilized in the development of molecular probes and labeled compounds for biological target identification and study.
• Library Synthesis for Drug Discovery: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in medicinal chemistry.

Basic Information

Product Name	7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,4-Tetrahydroquinoline
CAS No.	1235142-07-0
Molecular Formula	C15H22BNO2
Molecular Weight	259.15 g/mol
Synonyms	1,2,3,4-Tetrahydro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroquinoline; 7-Tetrahydroquinolineboronic acid pinacol ester; 7-(Pinacolatoboryl)-1,2,3,4-tetrahydroquinoline; Quinoline, 1,2,3,4-tetrahydro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 7-Boronic acid, 1,2,3,4-tetrahydroquinoline-, pinacol ester
EINECS	Contact for details

Quality Control

Our 7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, and well-ventilated place. Keep away from oxidizing agents. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.