Description

2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3,4-Thiadiazole CAS NO 1234706-95-6 is a high-value, heterocyclic boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its primary commercial value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing the 1,3,4-thiadiazole pharmacophore.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science: Building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Research & Development: Enables the exploration of new chemical space in medicinal chemistry and catalyst design via palladium-catalyzed cross-coupling.
• Ligand Synthesis: Intermediate for the preparation of specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP conditions where applicable.

Basic Information

Product Name	2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3,4-Thiadiazole
CAS No.	1234706-95-6
Molecular Formula	C9H15BN2O2S
Molecular Weight	226.10 g/mol
Synonyms	2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,4-thiadiazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methyl-1,3,4-thiadiazole; 2-Methyl-1,3,4-thiadiazole-5-boronic acid pinacol ester; 2-Methyl-5-(pinacolatoboryl)-1,3,4-thiadiazole; 1,3,4-Thiadiazole-5-boronic acid, 2-methyl-, pinacol ester; Pinacol 2-methyl-1,3,4-thiadiazole-5-boronate; 2-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-[1,3,4]thiadiazole
EINECS	Contact for details

Quality Control

Every batch of our 2-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,3,4-Thiadiazole is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.