Description

Phosphoric Acid Chloromethyl Ester Bis-(2-Trimethylsilanyl-Ethyl) Ester is a specialized organosilicon-protected phosphorochloridate reagent, a key intermediate in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of phosphate groups under mild conditions, which is critical for constructing complex molecules with high selectivity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of nucleotide analogs, prodrugs, and other bioactive phosphate esters. Its unique structure offers enhanced stability and reactivity profiles compared to traditional phosphorylating agents.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of nucleotide and nucleoside analogs used in antiviral and anticancer therapies.
• Prodrug Synthesis: Employed in the phosphorylation of hydroxyl groups to create biologically active phosphate prodrugs with improved bioavailability.
• Agrochemical Development: Used in the production of advanced herbicides and insecticides that contain phosphate ester functional groups.
• Peptide & Protein Modification: Facilitates site-specific phosphorylation of serine, threonine, or tyrosine residues in peptides for biochemical research.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the synthesis of specialty phosphorous-containing polymers and materials.
• Chemical Biology Tool: Used to prepare affinity probes and labeled compounds for studying phosphotransferase enzymes and signal transduction pathways.
• Ligand Synthesis for Catalysis: A precursor for chiral phosphine-phosphite and other bidentate ligands used in asymmetric catalysis.

Basic Information

Product Name	Phosphoric Acid Chloromethyl Ester Bis-(2-Trimethylsilanyl-Ethyl) Ester
CAS No.	1234692-55-7
Molecular Formula	C11H26ClO4PSi2
Molecular Weight	344.91 g/mol
Synonyms	Bis(2-(trimethylsilyl)ethyl) chloromethyl phosphate; Chloromethyl bis(2-(trimethylsilyl)ethyl) phosphate; Phosphorochloridic acid, chloromethyl ester, bis(2-(trimethylsilyl)ethyl) ester; (Chloromethoxy)phosphoryl dichloride bis(TMS-ethyl) ester; TMS-ethyl protected chloromethyl phosphorochloridate; Bis(TMSE) chloromethyl phosphorochloridate; TMSE-protected chloromethyl phosphate
EINECS	Contact for details

Quality Control

Every batch of Phosphoric Acid Chloromethyl Ester Bis-(2-Trimethylsilanyl-Ethyl) Ester is manufactured and analyzed under strict quality management systems. We ensure high purity and consistency through advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and cGMP-compliant production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent decomposition. Keep away from heat, sparks, open flames, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chloride Content (Titration)	Conforms
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.