Description

1-tert-Butyl 4-Ethyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Dihydropyridine-1,4(2H)-Dicarboxylate is a high-value, protected boronic ester derivative crucial for modern synthetic chemistry. This compound serves as a versatile and stable advanced pharmaceutical intermediate, enabling efficient carbon-carbon bond formation via cross-coupling reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex dihydropyridine or piperidine cores.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a critical boron-containing coupling partner for the palladium-catalyzed formation of biaryl and other C-C bonds, a cornerstone of medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic structures.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysts, and other functional organic molecules.
• Chemical Biology & Probe Development: Useful for creating molecular probes and labeled compounds for biological target identification and mechanism-of-action studies.
• Process Chemistry & Scale-Up: Suitable for optimization and scaling from laboratory gram-scale to pilot plant kilogram-scale production under controlled GMP-like conditions.

Basic Information

Product Name	1-tert-Butyl 4-Ethyl 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6-Dihydropyridine-1,4(2H)-Dicarboxylate
CAS No.	1234175-05-3
Molecular Formula	C23H38BNO6
Molecular Weight	435.36 g/mol
Synonyms	1-(tert-Butyl) 4-ethyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,4,5,6-tetrahydropyridine-1,4-dicarboxylate; 1-Boc-4-COOEt-3-(PinB)-1,4,5,6-tetrahydropyridine; tert-Butyl 4-ethoxycarbonyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydro-2H-pyridine-1-carboxylate; 3-Pinacolatoboryl-1,4,5,6-tetrahydropyridine-1,4-dicarboxylic acid 1-tert-butyl 4-ethyl ester; 1-Boc-3-(pinacolatoboryl)-1,2,3,6-tetrahydropyridine-4-carboxylic acid ethyl ester; BOC-3-PinB-1,2,3,6-THP-4-COOEt; CAS 1234175-05-3
EINECS	Contact for details

Quality Control

Our production of this high-purity boronic ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development and commercial projects with specifications that can meet the demands of cGMP and ISO 9001 quality management systems upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.