Description

tert-Butyl 4-(2-Hydroxy-2-Methylpropanamido)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a Boc (tert-butoxycarbonyl) group and functionalized with a hydroxypivalamide side chain. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of complex bioactive molecules. It is primarily utilized by pharmaceutical companies and research institutions in the development of new therapeutic agents, particularly in areas requiring sophisticated amine chemistry and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology drug candidates.
• Medicinal Chemistry R&D: Used in lead optimization and structure-activity relationship (SAR) studies to modify pharmacokinetic properties and enhance drug efficacy.
• Peptidomimetic Synthesis: Serves as a constrained scaffold for creating peptide analogs and mimetics with improved metabolic stability.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and receptor-ligand interactions.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Library Synthesis: Used in combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	tert-Butyl 4-(2-Hydroxy-2-Methylpropanamido)Piperidine-1-Carboxylate
CAS No.	1233952-42-5
Molecular Formula	C14H26N2O4
Molecular Weight	286.37 g/mol
Synonyms	1-Boc-4-(2-Hydroxy-2-methylpropanamido)piperidine; 4-(2-Hydroxy-2-methylpropanamido)piperidine-1-carboxylic acid tert-butyl ester; N-(1-Boc-4-piperidinyl)-2-hydroxy-2-methylpropanamide; 2-Hydroxy-2-methyl-N-(1-{[(2-methyl-2-propanyl)oxy]carbonyl}-4-piperidinyl)propanamide; tert-Butyl 4-(hydroxypivalamido)piperidine-1-carboxylate; 1-Boc-4-(hydroxypivalamido)piperidine; BOC-Pip-HPAA; 4-(HPAA)-1-Boc-piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2-Hydroxy-2-Methylpropanamido)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our production adheres to cGMP guidelines where applicable, ensuring suitability for advanced research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.