Description

3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Butanenitrile is a high-value, multifunctional chemical building block that combines a pyrazole core with a pinacol boronate ester and a nitrile functional group. This unique structure makes it a critical intermediate for Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for constructing novel active compounds. The compound, with CAS number 1233526-43-6, is supplied to meet the stringent purity requirements of advanced synthetic chemistry.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry for creating novel heterocyclic compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its boronate ester for structure-activity relationship (SAR) studies.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the synthesis of advanced polymers and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and bioconjugates for target identification and biochemical assays.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds, a cornerstone of modern organic synthesis.
• Library Synthesis for High-Throughput Screening: An essential component for generating diverse compound libraries in drug discovery programs.

Basic Information

Product Name	3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Butanenitrile
CAS No.	1233526-43-6
Molecular Formula	C13H20BN3O2
Molecular Weight	261.13 g/mol
Synonyms	4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]butyronitrile; 3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]butyronitrile; 1H-Pyrazole-1-butanenitrile, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-butanenitrile; 3-(4-(Pinacolatoboryl)-1H-pyrazol-1-yl)butanenitrile; 4-(Pinacolatoboryl)-1-(3-cyanopropyl)pyrazole; 1-(3-Cyanopropyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
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Quality Control

Our 3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Butanenitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.