Description

1-(Tetrahydro-1,1-Dioxido-3-Thienyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-purity, advanced pharmaceutical intermediate and building block featuring a pyrazole core with a tetrahydrothiophene dioxide moiety and a pinacol boronate ester. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl and heterobiaryl structures. It is an essential raw material for research and development chemists in the pharmaceutical and agrochemical industries, enabling the synthesis of novel active ingredients targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in oncology, CNS disorders, and anti-infective research.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester group makes it a versatile partner for palladium-catalyzed coupling with aryl/heteroaryl halides, enabling efficient carbon-carbon bond formation.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require complex heterocyclic architectures.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Supplied in development and commercial quantities to support route scouting, optimization, and GMP manufacturing campaigns.

Basic Information

Product Name	1-(Tetrahydro-1,1-Dioxido-3-Thienyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1233526-31-2
Molecular Formula	C₁₃H₂₁BN₂O₄S
Molecular Weight	312.19 g/mol
Synonyms	1-(Tetrahydro-1,1-dioxido-3-thienyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(Tetrahydrothiophene-1,1-dioxide-3-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(tetrahydrothiophen-3-yl)-1H-pyrazole 1,1-dioxide; 3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]thiolane 1,1-dioxide; CAS 1233526-31-2; Pinacol [1-(1,1-Dioxidotetrahydro-3-thienyl)-1H-pyrazol-4-yl]boronate
EINECS	Contact for details

Quality Control

Our production of 1-(Tetrahydro-1,1-Dioxido-3-Thienyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis to ensure it meets the exacting standards required for pharmaceutical R&D and process chemistry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.