Description

1-[[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Methyl]Cyclopropanecarbonitrile is a high-value, multi-functional chemical building block that integrates a cyclopropane nitrile moiety with a protected boronic ester functionalized pyrazole. This compound matters for its versatility in modern synthetic chemistry, serving as a critical intermediate in the construction of complex molecules for pharmaceutical and agrochemical discovery. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for applications in Suzuki-Miyaura cross-coupling reactions and as a precursor for bioactive compound libraries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrazole and cyclopropane motifs.
• Material Science Research: Serves as a monomer or functional additive in the development of advanced polymers and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular probe or linker in activity-based protein profiling (ABPP) and bioconjugation strategies.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronic ester group makes it an essential reagent for forming carbon-carbon bonds in medicinal and process chemistry.
• Library Synthesis for High-Throughput Screening: A valuable scaffold for generating diverse compound libraries to identify new biological leads.

Basic Information

Product Name	1-[[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Methyl]Cyclopropanecarbonitrile
CAS No.	1233526-27-6
Molecular Formula	C14H20BN3O2
Molecular Weight	273.14 g/mol
Synonyms	1-[(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl]cyclopropanecarbonitrile; Cyclopropanecarbonitrile, 1-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl]-; 1-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)cyclopropane-1-carbonitrile; 1-(4-Pinacolatoboron-1H-pyrazol-1-ylmethyl)cyclopropanecarbonitrile; (1-(Cyanocyclopropyl)methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
EINECS	Contact for details

Quality Control

Our 1-[[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Methyl]Cyclopropanecarbonitrile is manufactured under strict quality management systems. All batches undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.