Description

2,2-Difluoro-3-Hydroxypentanoic Acid is a fluorinated hydroxy acid derivative that serves as a versatile and valuable building block in advanced organic synthesis. Its unique structure, featuring both fluorine atoms and a hydroxyl group on a carboxylic acid backbone, makes it a critical intermediate for introducing specific stereochemistry and reactivity into target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its fluorinated motif can enhance metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the difluoro group can improve lipophilicity and biological activity.
• Advanced Material Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers and fluorinated materials with unique surface properties.
• Chemical Biology Probe Development: Employed in medicinal chemistry to create tool compounds and probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic & Industrial Research: Utilized in university and corporate R&D labs for methodological development in fluorination chemistry and asymmetric synthesis.

Basic Information

Product Name	2,2-Difluoro-3-Hydroxypentanoic Acid
CAS No.	1233233-76-5
Molecular Formula	C5H8F2O3
Molecular Weight	154.11 g/mol
Synonyms	3-Hydroxy-2,2-difluoropentanoic Acid; 2,2-Difluoro-3-hydroxypentanoic Acid; Pentanoic acid, 2,2-difluoro-3-hydroxy-; α,α-Difluoro-β-hydroxypentanoic Acid
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-3-Hydroxypentanoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the exacting standards required for research and development applications. A detailed Certificate of Analysis (COA), including results for purity (HPLC), identity (NMR, IR), and specific impurity profiles, is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.