Description

1-(2-Bromo-5-Trifluoromethylphenyl)-Ethanone is a high-purity, multi-functional organic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for facilitating advanced cross-coupling reactions and introducing fluorinated motifs into target molecules, which is critical for modulating the physicochemical properties of advanced materials and active pharmaceutical ingredients. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel compounds.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group contributes to biological activity and environmental persistence.
• Material Science: Acts as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for studying the effects of fluorine substitution on chemical reactivity and physical properties.
• Ligand and Catalyst Development: Employed in the synthesis of novel phosphine or N-heterocyclic carbene ligands for asymmetric catalysis.

Basic Information

Item	Details
Product Name	1-(2-Bromo-5-Trifluoromethylphenyl)-Ethanone
CAS No.	1232407-41-8
Molecular Formula	C9H6BrF3O
Molecular Weight	267.05 g/mol
Synonyms	2'-Bromo-5'-(trifluoromethyl)acetophenone; 2-Bromo-α,α,α-trifluoro-p-acetophenone; 1-Acetyl-2-bromo-5-(trifluoromethyl)benzene; 2-Bromo-5-trifluoromethylacetophenone; α,α,α-Trifluoro-2-bromoacetophenone; 2-Bromo-α,α,α-trifluoroacetophenone; (2-Bromo-5-(trifluoromethyl)phenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Every batch of 1-(2-Bromo-5-Trifluoromethylphenyl)-Ethanone is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring the material meets the stringent requirements for use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.