Description

7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydroisoquinolin-1(2H)-One is a high-value, advanced pharmaceutical intermediate and building block featuring a pinacol boronate ester functional group. This compound is critical for modern synthetic chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction to construct complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds for constructing biaryl and heterobiaryl structures, a cornerstone of modern organic synthesis.
• Agrochemical Research: Used in the discovery and development of new pesticides and herbicides, where the isoquinolinone scaffold can impart specific biological activity.
• Material Science: Serves as a precursor for organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors.
• Chemical Biology & Proteomics: Can be employed as a molecular probe or tag in bioconjugation and labeling strategies due to its reactive boronate group.
• Academic & Contract Research: Essential for synthetic methodology development and scale-up studies in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydroisoquinolin-1(2H)-One
CAS No.	1231892-74-2
Molecular Formula	C15H20BNO3
Molecular Weight	273.14 g/mol
Synonyms	1,2,3,4-Tetrahydro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1-one; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydroisoquinolin-1-one; 7-(Pinacolatoboryl)-3,4-dihydroisoquinolin-1(2H)-one; 7-Borono-3,4-dihydroisoquinolin-1(2H)-one pinacol ester; 7-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-1H-isoquinolin-1-one; 7-Boronodihydroisoquinolinone pinacol ester
EINECS	Contact for details

Quality Control

Our production of 7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydroisoquinolin-1(2H)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.