Description

tert-Butyl 3,3-Dimethyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine boronic ester moiety. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex organic molecules and heterocycles.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry & Lead Optimization: Used for the rapid exploration of structure-activity relationships (SAR) by introducing the boronate functional group into molecular scaffolds.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Agrochemical Research: Utilized in the synthesis of novel compounds for crop protection and agrochemical discovery.
• Material Science Precursor: Acts as a specialized monomer or precursor in the synthesis of advanced organic materials and polymers.

Basic Information

Product Name	tert-Butyl 3,3-Dimethyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine-1-Carboxylate
CAS No.	1228962-22-8
Molecular Formula	C18H34BNO4
Molecular Weight	339.28 g/mol
Synonyms	1-Boc-3,3-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine; 1-(tert-Butoxycarbonyl)-3,3-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3,3-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine; tert-Butyl 3,3-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,3-Dimethyl-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.