Description

1-(2-Bromo-5-Chlorophenyl)-4,4,4-Trifluorobutan-1-One is a high-purity, specialized fluorinated aromatic ketone building block. This compound is valued for its unique trifluoromethyl and halogen-substituted phenyl structure, which is critical for modulating the physicochemical properties of advanced molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its specific halogen pattern and fluorine content are leveraged to enhance metabolic stability, lipophilicity, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory pathways.
• Agrochemical Synthesis: Serves as a crucial building block for creating advanced herbicides, fungicides, and insecticides, where the fluorine and halogen atoms contribute to improved efficacy and environmental profile.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics and aromatic core.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological systems and enzyme activity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in custom synthesis projects and scale-up processes.

Basic Information

Product Name	1-(2-Bromo-5-Chlorophenyl)-4,4,4-Trifluorobutan-1-One
CAS No.	1228788-14-4
Molecular Formula	C10H7BrClF3O
Molecular Weight	315.51 g/mol
Synonyms	2-Bromo-5-chloro-α,α,α-trifluoroacetophenone; 4,4,4-Trifluoro-1-(2-bromo-5-chlorophenyl)butan-1-one; 1-(2-Bromo-5-chlorophenyl)-4,4,4-trifluorobutanone; 2'-Bromo-5'-chloro-4,4,4-trifluorobutyrophenone; α,α,α-Trifluoro-2-bromo-5-chloroacetophenone; Butan-1-one, 1-(2-bromo-5-chlorophenyl)-4,4,4-trifluoro-; (2-Bromo-5-chlorophenyl)(3,3,3-trifluoropropyl)methanone
EINECS	Contact for details

Quality Control

Our 1-(2-Bromo-5-Chlorophenyl)-4,4,4-Trifluorobutan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.