Description

Ethyl(1R,3S,4S)-3-Fluoro-4-Hydroxycyclohexane-1-Carboxylate is a high-value, stereochemically defined fluorinated cyclohexane derivative. This compound serves as a critical chiral building block and advanced intermediate in modern synthetic organic chemistry, enabling the precise introduction of fluorine and hydroxyl functionalities. It is primarily sought after by pharmaceutical and agrochemical R&D organizations for the synthesis of novel active ingredients, where its specific stereochemistry and fluorine atom are essential for modulating biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides to enhance efficacy and environmental profile.
• Asymmetric Catalysis & Method Development: Serves as a valuable substrate or ligand precursor in academic and industrial research focused on new fluorination and hydroxylation methodologies.
• Material Science Precursor: Potential use in synthesizing specialty fluorinated monomers for advanced polymers with unique surface properties.
• Chemical Biology Probe Development: Employed in the construction of molecular probes to study enzyme mechanisms and biological pathways involving fluorine interactions.

Basic Information

Item	Detail
Product Name	Ethyl(1R,3S,4S)-3-Fluoro-4-Hydroxycyclohexane-1-Carboxylate
CAS No.	1228360-09-5
Molecular Formula	C9H15FO3
Molecular Weight	190.21 g/mol
Synonyms	(1R,3S,4S)-Ethyl 3-Fluoro-4-hydroxycyclohexanecarboxylate; Ethyl (1R,3S,4S)-3-Fluoro-4-hydroxycyclohexane-1-carboxylate; (1R,3S,4S)-3-Fluoro-4-hydroxycyclohexanecarboxylic Acid Ethyl Ester; trans-Ethyl 3-Fluoro-4-hydroxycyclohexanecarboxylate (stereospecific); Fluorocyclohexanol Carboxylate Ester; CAS 1228360-09-5
EINECS	Contact for details

Quality Control

Every batch of Ethyl(1R,3S,4S)-3-Fluoro-4-Hydroxycyclohexane-1-Carboxylate is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure the material meets the stringent requirements for advanced research and process development. Certificates of Analysis (COA) detailing identity, purity (by HPLC/GC), enantiomeric excess, and impurity profiles are supplied with each shipment. Our quality protocols are designed to support cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.