Description

3,3-Difluoro-Azepane Hydrochloride is a high-purity, functionalized azepane derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic incorporation of fluorine atoms and a secondary amine salt, which are pivotal for modulating the physicochemical and biological properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the difluoroazepane moiety can enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts in asymmetric synthesis.
• Chemical Biology Probe: Utilized in medicinal chemistry to create tool compounds for target validation and mechanistic studies.
• Material Science Research: Investigated as a monomer or additive for specialty polymers with unique properties.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-quality, complex heterocyclic building blocks.

Basic Information

Product Name	3,3-Difluoro-Azepane Hydrochloride
CAS No.	1228231-35-3
Molecular Formula	C6H12ClF2N
Molecular Weight	171.62 g/mol
Synonyms	3,3-Difluoroazepane HCl; 3,3-Difluorohexamethyleneimine Hydrochloride; Azepane, 3,3-difluoro-, hydrochloride; 1-Aza-3,3-difluorocycloheptane Hydrochloride; 3,3-Difluoro-1-azacycloheptane Hydrochloride; 3,3-Difluoroperhydroazepine Hydrochloride; 3,3-Difluoroazepan-1-ium Chloride
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-Azepane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.