Description

B-[3-(4-Acetyl-1-Piperazinyl)Phenyl]Boronic Acid CAS NO 1228182-95-3 is a sophisticated boronic acid derivative featuring a piperazine-acetyl pharmacophore, making it a valuable building block in modern synthetic chemistry. Its primary value lies in its role as a key intermediate in the synthesis of complex molecules, particularly through Suzuki-Miyaura cross-coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, as well as in advanced material science for creating novel organic frameworks.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets, kinase inhibitors, and other therapeutic agents where the piperazine moiety is pharmacologically relevant.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its structural complexity to create compounds with specific biological activity.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner for forming carbon-carbon bonds with aryl or vinyl halides, a cornerstone reaction in medicinal chemistry and material science.
• Chemical Biology & Proteomics: Can be utilized in the development of chemical probes and affinity ligands for studying protein function and interactions due to its potential for bioconjugation.
• Advanced Material Science: Acts as a monomer or linker in the synthesis of organic polymers, covalent organic frameworks (COFs), and other functional materials requiring precise molecular architecture.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in cutting-edge organic synthesis and methodology development.

Basic Information

Product Name	B-[3-(4-Acetyl-1-Piperazinyl)Phenyl]Boronic Acid
CAS No.	1228182-95-3
Molecular Formula	C12H17BN2O3
Molecular Weight	248.09 g/mol
Synonyms	[3-(4-Acetylpiperazin-1-yl)phenyl]boronic acid; 3-(4-Acetyl-1-piperazinyl)benzeneboronic acid; (3-(4-Acetylpiperazin-1-yl)phenyl)boronic acid; 1-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-acetylpiperazine (Pinacol ester precursor); B-(3-(4-Acetylpiperazin-1-yl)phenyl)boronic acid
EINECS	Contact for details

Quality Control

Our B-[3-(4-Acetyl-1-Piperazinyl)Phenyl]Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We support development and commercial projects with material that meets the stringent requirements for pharmaceutical R&D and other advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.