Description

Benzenesulfonamide, n-(2-Aminoethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multifunctional chemical building block that combines a benzenesulfonamide scaffold with a reactive aminoethyl linker and a pinacol boronate ester group. This compound matters for its dual functionality, serving as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in Suzuki-Miyaura cross-coupling reactions and as a precursor for bioactive molecule libraries.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in creating boron-containing protease inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety makes it an excellent reagent for palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures.
• Chemical Biology & Proteomics: Used in the development of activity-based probes and affinity tags due to the reactive amino group and the sulfonamide moiety.
• Agrochemical Research: Serves as an intermediate in the design and synthesis of new generation herbicides and fungicides with improved efficacy.
• Material Science: Employed in the development of organic electronic materials and metal-organic frameworks (MOFs) where precise molecular architecture is required.
• Library Synthesis for High-Throughput Screening: Utilized in combinatorial chemistry to generate diverse compound libraries for biological screening campaigns.

Basic Information

Product Name	Benzenesulfonamide, n-(2-Aminoethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1228148-98-8
Molecular Formula	C14H23BN2O4S
Molecular Weight	326.22 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2-aminoethyl)benzenesulfonamide; 2-({[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]sulfonyl}amino)ethan-1-amine; N-(2-Aminoethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide; 4-BPin-NHETBSA; Aminoethyl BPin Benzenesulfonamide; (4-((2-Aminoethyl)sulfamoyl)phenyl)boronic acid pinacol ester; B-[4-[[(2-Aminoethyl)amino]sulfonyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our Benzenesulfonamide, n-(2-Aminoethyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.