Description

5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(2-(Trimethylsilyloxy)Propan-2-Yl)Pyridine is a highly functionalized, advanced pharmaceutical intermediate that combines a protected boronic ester with a silyl-protected alcohol group on a pyridine scaffold. This compound matters because it serves as a critical building block for the synthesis of complex molecules, enabling efficient cross-coupling reactions and protecting group strategies in a single entity. Pharmaceutical R&D and fine chemical synthesis teams need it to accelerate the development of new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially for targeted therapies.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester functionality enables efficient carbon-carbon bond formation with aryl halides, a cornerstone of modern medicinal chemistry.
• Protected Building Block Synthesis: The trimethylsilyloxy (TMS) group protects the alcohol, allowing for selective deprotection and further functionalization in multi-step syntheses.
• Ligand and Catalyst Development: Used in the research and preparation of novel ligands for catalysis or metal-organic frameworks (MOFs).
• Agrochemical Research: Serves as an intermediate in the development of new, high-performance crop protection agents.
• Material Science: Employed in the creation of organic electronic materials and functional polymers.

Basic Information

Product Name	5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-(2-(Trimethylsilyloxy)Propan-2-Yl)Pyridine
CAS No.	1228014-10-5
Molecular Formula	C19H32BNO3Si
Molecular Weight	361.36 g/mol
Synonyms	2-(2-(Trimethylsilyloxy)propan-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[2-(trimethylsilyloxy)propan-2-yl]pyridine; Pinacol 2-(2-(Trimethylsilyloxy)propan-2-yl)pyridine-5-boronate; 2-(1-Hydroxy-1-methylethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine TMS ether; CAS 1228014-10-5
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 11B), and GC/MS, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use in GMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening to prevent degradation. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.