Description

3-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole is a high-value, synthetically versatile boronic ester derivative of the indazole heterocycle. This compound matters as a critical pharmaceutical intermediate and Suzuki-Miyaura cross-coupling building block, enabling the efficient construction of complex molecules for drug discovery. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to incorporate functionalized indazole scaffolds into their target compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester pinacol group enables efficient palladium-catalyzed coupling with aryl/heteroaryl halides to form biaryl linkages.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and for the structure-activity relationship (SAR) optimization of lead compounds containing the indazole core.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Potential monomer or functional unit in the development of organic electronic materials, such as OLEDs or conductive polymers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced chemical synthesis for global clients.

Basic Information

Product Name	3-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole
CAS No.	1227911-51-4
Molecular Formula	C₁₄H₁₉BN₂O₂
Molecular Weight	258.13 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methyl-1H-indazole; 3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 1H-Indazole, 3-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 3-Methyl-1H-indazole-6-boronic acid pinacol ester; 6-Borono-3-methyl-1H-indazole pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity during use. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.