Description

2-(8-Fluoronaphthalen-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is a critical reagent in modern cross-coupling reactions, enabling the efficient construction of complex fluorinated aromatic systems. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key boronic ester pinacol ester reagent for palladium-catalyzed C-C bond formation with aryl halides.
• Pharmaceutical Intermediate: Synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Development: Building block for novel pesticides and herbicides that incorporate fluoronaphthalene motifs for enhanced bioactivity and stability.
• Organic Light-Emitting Diodes (OLEDs): Precursor for electron-transport materials and emissive layer components in display technology.
• Liquid Crystal and Polymer Synthesis: Monomer for creating fluorinated aromatic polymers with specific thermal and optical properties.
• Chemical Research & Development: Versatile scaffold for medicinal chemistry and material science exploration.

Basic Information

Product Name	2-(8-Fluoronaphthalen-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1227828-00-3
Molecular Formula	C₁₆H₂₀BFO₂
Molecular Weight	274.14 g/mol
Synonyms	2-(8-Fluoronaphthalen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 8-Fluoro-2-naphthaleneboronic acid pinacol ester; 2-(8-Fluoro-2-naphthyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 8-Fluoronaphthalene-2-boronic acid pinacol ester; 2-(8-Fluoronaphthalen-2-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; 8-Fluoro-2-naphthylboronic acid pinacol ester; (8-Fluoronaphthalen-2-yl)boronic acid pinacol ester; 1227828-00-3
EINECS	Contact for details

Quality Control

Every batch of 2-(8-Fluoronaphthalen-2-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed under an inert atmosphere such as nitrogen or argon to maximize shelf-life stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.