Description

4-(Trifluoromethyl)Pyridinyl-2-Boronic Acid Mida Ester is a high-value, advanced pharmaceutical intermediate and building block for organic synthesis. This compound matters as a protected boronic acid derivative, offering superior stability and handling properties compared to its free boronic acid counterpart, which is critical for complex multi-step reactions. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients, particularly in cross-coupling reactions like Suzuki-Miyaura.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing the trifluoromethylpyridine moiety for enhanced metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials and ligands for catalysis.
• Suzuki-Miyaura Cross-Coupling: The Mida ester protecting group provides a stable, yet activatable, source of the boronic acid functionality for efficient palladium-catalyzed C-C bond formation.
• Medicinal Chemistry & Drug Discovery: Enables the rapid exploration of chemical space by facilitating the introduction of the 4-(trifluoromethyl)pyridin-2-yl group into candidate molecules.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying biological systems.

Basic Information

Product Name	4-(Trifluoromethyl)Pyridinyl-2-Boronic Acid Mida Ester
CAS No.	1227700-48-2
Molecular Formula	C10H9BF3N2O2
Molecular Weight	260.00 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine 1,3-Dimethylimidazolidin-2-one Complex; 4-(Trifluoromethyl)pyridine-2-boronic acid MIDA ester; N-Methyliminodiacetic acid (MIDA) boronate ester of 2-(4-(Trifluoromethyl)pyridinyl)boronic acid; [2-(4-Trifluoromethyl-2-pyridinyl)-1,3,2-dioxaborolan-4,5-dicarboxylic acid] dimethylimide; 2-(4-(Trifluoromethyl)pyridin-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane-4,6-dione (alternative representation); B-[4-(Trifluoromethyl)-2-pyridinyl]-N-methyliminodiacetic acid boronate
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Pyridinyl-2-Boronic Acid Mida Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP, ICH Q7, and other relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent hydrolysis of the Mida ester group. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.