Description

6-Methoxypyridine-2-Boronic Acid Mida Ester CAS NO 1227700-45-9 is a high-value, protected boronic acid derivative designed for advanced synthetic chemistry. Its core value lies in the MIDA (N-methyliminodiacetic acid) ester group, which stabilizes the boronic acid moiety, enhancing its shelf-life and handling properties for complex, multi-step reactions. This compound is essential for researchers and process chemists in pharmaceutical and agrochemical development, particularly for Suzuki-Miyaura cross-coupling reactions to construct biaryl and heterobiaryl scaffolds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) containing the 6-methoxypyridine motif.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for catalysts or components for organic light-emitting diodes (OLEDs).
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-tolerant boronic acid equivalent for palladium-catalyzed carbon-carbon bond formation.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry.
• Chemical Biology Probes: Used to create tagged molecules for studying biological processes and target engagement.

Basic Information

Item	Detail
Product Name	6-Methoxypyridine-2-Boronic Acid Mida Ester
CAS No.	1227700-45-9
Molecular Formula	C10H13BN2O5
Molecular Weight	252.03 g/mol
Synonyms	2-(6-Methoxypyridin-2-yl)-1,3,2-dioxaborinane-4,6-dione N-Methyliminodiacetic Acid Ester; 6-Methoxy-2-pyridineboronic acid MIDA ester; N-Methyliminodiacetic Acid Boronate Ester of 6-Methoxypyridine-2-boronic Acid; 2-(6-Methoxypyridin-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane-4,6-dione; MIDA Boronate of 6-Methoxy-2-pyridinylboronic Acid; 6-Methoxy-2-pyridylboronic acid MIDA ester; (6-Methoxypyridin-2-yl)boronic acid MIDA ester
EINECS	Contact for details

Quality Control

Our 6-Methoxypyridine-2-Boronic Acid Mida Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full specification data are provided to guarantee the material meets the rigorous standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.