Description

6-Methylpyridinyl-2-Boronic Acid Mida Ester is a high-value, protected boronic acid derivative designed for advanced synthetic chemistry. This compound is crucial for enabling robust, shelf-stable Suzuki-Miyaura cross-coupling reactions, offering superior handling characteristics compared to its free boronic acid counterpart. It is an essential building block for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those containing functionalized pyridine scaffolds.
• Suzuki-Miyaura Cross-Coupling: A stable, air- and moisture-tolerant reagent for palladium-catalyzed carbon-carbon bond formation, enabling the construction of biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science: Precursor for creating organic electronic materials and metal-organic frameworks (MOFs) with tailored properties.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the development of activity-based probes.
• Process Chemistry & Scale-up: Its enhanced stability makes it ideal for multi-step synthesis and large-scale manufacturing processes.

Basic Information

Product Name	6-Methylpyridinyl-2-Boronic Acid Mida Ester
CAS No.	1227700-42-6
Molecular Formula	C9H11BN2O2
Molecular Weight	190.01 g/mol
Synonyms	2-(6-Methylpyridin-2-yl)-1,3,2-dioxaborolane-4,6-dione N-methyliminodiacetic ester; 6-Methyl-2-pyridineboronic acid MIDA ester; N-Methyliminodiacetic acid boronate ester of 6-methylpyridine-2-boronic acid; 6-Methylpyridine-2-boronic acid MIDA ester; 2-(6-Methyl-2-pyridinyl)-5,5-dimethyl-1,3,2-dioxaborinane; MIDA Boronate of 6-Methylpyridin-2-ylboronic Acid
EINECS	Contact for details

Quality Control

Our 6-Methylpyridinyl-2-Boronic Acid Mida Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.