Description

2-Thiophenecarboxylic Acid, 5-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. This compound, with CAS number 1227664-24-5, is prized for its role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity reagents for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing functionalized thiophene cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science: Serves as a precursor for organic electronic materials, such as conductive polymers and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds between aromatic and heteroaromatic systems.
• Chemical Research & Development: A versatile reagent for medicinal chemistry and process chemistry for creating diverse compound libraries.
• Ligand and Catalyst Development: Potential use in the synthesis of novel ligands and organometallic catalysts.

Basic Information

Item	Details
Product Name	2-Thiophenecarboxylic Acid, 5-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester
CAS No.	1227664-24-5
Molecular Formula	C12H16BClO4S
Molecular Weight	302.58 g/mol
Synonyms	Methyl 5-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate; 5-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 5-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 5-chloro-4-(pinacolatoboron)thiophene-2-carboxylate; 5-Chloro-4-(pinacolatoboron)thiophene-2-carboxylic acid methyl ester; CAS 1227664-24-5
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarboxylic Acid, 5-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.