Description

2-(Methoxycarbonyl)Indole-3-Boronic Acid Pinacol Ester is a high-value, protected boronic acid derivative that serves as a crucial synthetic intermediate. Its primary value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, to construct complex indole-based molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing indole-containing drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Enables the creation of functional organic molecules for organic light-emitting diodes (OLEDs) and other electronic materials.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the development of molecular probes.
• Academic & Contract Research: A vital reagent for methodology development and complex molecule synthesis in R&D laboratories.
• Scale-up Process Chemistry: Suitable for transitioning from milligram-scale discovery to kilogram-scale production under optimized conditions.

Basic Information

Product Name	2-(Methoxycarbonyl)Indole-3-Boronic Acid Pinacol Ester
CAS No.	1227664-20-1
Molecular Formula	C₁₆H₂₀BNO₄
Molecular Weight	301.15 g/mol
Synonyms	Methyl 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-2-carboxylate; 1H-Indole-2-carboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; 2-Carbomethoxyindole-3-boronic acid pinacol ester; 3-Borono-1H-indole-2-carboxylic acid methyl ester pinacol ester; Methyl 3-boronoindole-2-carboxylate pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(Methoxycarbonyl)Indole-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and reliability for your critical synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.