Description

3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Thiophenecarboxylic Acid Methyl Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for modern cross-coupling reactions, enabling the efficient construction of complex heterocyclic molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced organic materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for introducing functionalized thiophene moieties into target molecules, crucial for creating complex chemical architectures.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potential drug candidates, particularly those containing thiophene heterocycles for various therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the thiophene scaffold imparts specific biological activity.
• Material Science & Organic Electronics: A precursor for synthesizing conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), field-effect transistors (OFETs), and photovoltaic cells.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and labeled compounds for studying biological processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthesis projects.

Basic Information

Product Name	3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Thiophenecarboxylic Acid Methyl Ester
CAS No.	1227664-10-9
Molecular Formula	C12H17BO4S
Molecular Weight	268.14 g/mol
Synonyms	Methyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylic acid methyl ester; Methyl 3-(pinacolatoboryl)thiophene-2-carboxylate; 3-Pinacolatoboryl-2-thiophenecarboxylic acid methyl ester; 3-Boronic acid, thiophene-2-carboxylic acid methyl ester, pinacol ester; Pinacol 3-(methoxycarbonyl)thiophen-2-ylboronate
EINECS	Contact for details

Quality Control

Our 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Thiophenecarboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.