Description

5-Chloro-3-(trifluoromethyl)-2-pyridinecarboxaldehyde is a versatile and high-value pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and trifluoromethyl substituents, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing character.
• Custom Synthesis and Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-Chloro-3-(trifluoromethyl)-2-pyridinecarboxaldehyde
CAS No.	1227605-33-5
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	5-Chloro-3-(trifluoromethyl)picolinaldehyde; 2-Pyridinecarboxaldehyde, 5-chloro-3-(trifluoromethyl)-; 5-Chloro-3-trifluoromethylpyridine-2-carbaldehyde; 5-Chloro-3-(trifluoromethyl)-2-formylpyridine; 5-Chloro-3-(trifluoromethyl)picolinaldehyde; 1227605-33-5 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-3-(trifluoromethyl)-2-pyridinecarboxaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) including purity (HPLC), identity confirmation (IR, NMR), and impurity profile is supplied with each shipment to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage or after opening. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.