Description

3-Chloro-5-Fluoro-Pyridine-4-Carbaldehyde is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and fluoro substituents adjacent to the aldehyde group, makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce key pharmacophores and create novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its reactive aldehyde group.
• Custom Synthesis and Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	3-Chloro-5-Fluoro-Pyridine-4-Carbaldehyde
CAS No.	1227603-79-3
Molecular Formula	C6H3ClFNO
Molecular Weight	159.55 g/mol
Synonyms	4-Pyridinecarboxaldehyde, 3-chloro-5-fluoro-; 3-Chloro-5-fluoropyridine-4-carboxaldehyde; 3-Chloro-5-fluoro-4-formylpyridine; 3-Chloro-5-fluoro-4-pyridinecarbaldehyde; 1227603-79-3; 3-Chloro-5-fluoro-4-pyridinecarboxaldehyde; 3-Chloro-5-fluoropyridine-4-carbaldehyde
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-Fluoro-Pyridine-4-Carbaldehyde is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the high standards required for pharmaceutical and agrochemical applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.