Description

3-Bromo-2-Chloropyridine-4-Carboxaldehyde is a high-value halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an indispensable intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought by research chemists and process development scientists for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts in asymmetric synthesis.
• Material Science Research: Building block for synthesizing functionalized polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromo and chloro substituents make it an excellent substrate for sequential Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Chemical Biology Probes: Used to develop molecular probes and tags for studying biological systems and target engagement.

Basic Information

Product Name	3-Bromo-2-Chloropyridine-4-Carboxaldehyde
CAS No.	1227602-82-5
Molecular Formula	C6H3BrClNO
Molecular Weight	220.45 g/mol
Synonyms	2-Chloro-3-bromopyridine-4-carboxaldehyde; 4-Formyl-3-bromo-2-chloropyridine; 3-Bromo-2-chloroisonicotinaldehyde; 3-Bromo-2-chloro-4-pyridinecarboxaldehyde; 2-Chloro-3-bromo-4-formylpyridine; 3-Bromo-2-chloropyridine-4-carbaldehyde
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Chloropyridine-4-Carboxaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.