Description

3-Bromo-6-(Trifluoromethyl)Pyridine-2-Carbaldehyde is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromo and trifluoromethyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating novel ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or fluorinated polymers, due to its electron-withdrawing characteristics.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Library Development: A valuable building block for medicinal chemistry and high-throughput screening libraries aimed at drug discovery.

Basic Information

Product Name	3-Bromo-6-(Trifluoromethyl)Pyridine-2-Carbaldehyde
CAS No.	1227573-28-5
Molecular Formula	C7H3BrF3NO
Molecular Weight	253.99 g/mol
Synonyms	2-Bromo-5-(trifluoromethyl)pyridine-4-carbaldehyde; 3-Bromo-6-(trifluoromethyl)-2-pyridinecarboxaldehyde; 2-Pyridinecarboxaldehyde, 3-bromo-6-(trifluoromethyl)-; 3-Bromo-6-trifluoromethylpyridine-2-carbaldehyde; 3-Bromo-6-(trifluoromethyl)picolinaldehyde
EINECS	Contact for details

Quality Control

Our 3-Bromo-6-(Trifluoromethyl)Pyridine-2-Carbaldehyde is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the specific results against our stringent internal specifications. We are committed to supplying material that meets the exacting standards required for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.