Description

3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Propanamide is a specialized organoboron compound featuring a propanamide backbone protected by a tetramethyl dioxaborolane group. This molecular architecture makes it a valuable protected boronic acid derivative, crucial for advanced organic synthesis where stability and controlled reactivity are paramount. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of novel active ingredients and complex molecular scaffolds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key, stable boronic ester reagent for constructing carbon-carbon bonds in complex molecule synthesis.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for boron-containing drug candidates.
• Agrochemical Synthesis: Employed in creating novel pesticides and herbicides where the boron moiety can impart specific biological activity.
• Material Science Research: Acts as a building block for organic electronic materials, such as polymers and small molecules for OLEDs or sensors.
• Peptide Modification & Bioconjugation: Utilized for site-specific labeling or functionalization of biomolecules via reactions with the amide or protected boronic acid group.
• Library Synthesis for Drug Discovery: A valuable scaffold in combinatorial and medicinal chemistry for generating diverse compound libraries.

Basic Information

Item	Details
Product Name	3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Propanamide
CAS No.	1227359-70-7
Molecular Formula	C9H18BNO3
Molecular Weight	199.06 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)propanamide; Propanamide, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 3-(Tetramethyldioxaborolanyl)propanamide; 2-(3-Carbamoylpropyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; TMEDA-protected 3-boronopropanamide; Boric acid, (3-amino-3-oxopropyl)-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 3-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Propanamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets high-purity standards suitable for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.